Chemotherapy-induced peripheral neuropathy is a major dose-limiting side effect of commonly used chemotherapeutic agents.\r\nHowever, there are no effective strategies to treat the neuropathy.We examined whether Goshajinkigan, a herbal medicine, would\r\nprevent paclitaxel-induced allodynia without affecting the anticancer action in mice.Murine breast cancer 4T1 cells were inoculated\r\ninto the mammary fat pad. Paclitaxel (10 and 20mg/kg, intraperitoneal, alternate day from day 7 postinoculation) inhibited the\r\ntumor growth, and Goshajinkigan (1 g/kg, oral, daily from day 2 postinoculation) did not affect the antitumor action of paclitaxel.\r\nMechanical allodynia developed in the inoculated region due to tumor growth and in the hind paw due to paclitaxel-induced\r\nneuropathy. Paclitaxel-induced allodynia was markedly prevented by Goshajinkigan, although tumor-associated allodynia was not\r\ninhibited by Goshajinkigan. These results suggest that Goshajinkigan prevents paclitaxel-induced peripheral neuropathy without\r\ninterfering with the anti-cancer action of paclitaxel.
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